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. 2020 Jul 7;48(17):9415–9432. doi: 10.1093/nar/gkaa544

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — Universal patterns of nucleosome recognition. (A) Volcano plots for nucleosome binding changes in each disk patch mutant nucleosome relative to WT nucleosomes. Horizontal and vertical lines designate 5% FDR and 1.4-fold change significance thresholds, respectively. (B) Histogram illustrating number of proteins with significantly increased or decreased binding to indicated nucleosomes. (C) Upset plot showing number of proteins with significant decreases in subset of nucleosome pulldowns, marked below. (D) Heat map of all significantly changed proteins, independently clustered. (E) Selected acidic patch-dependent nucleosome binding proteins. *DEK is dependent on all but Nuc4 and Tfip11 and Actr6 are dependent on Nuc1 and Nuc3.