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. 2020 Aug 20;39(39):6172–6189. doi: 10.1038/s41388-020-01429-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Heatmap showing the differential percent splice index (PSI) of prostate-cancer-relevant genes between LNCaP cells cultured with 10-μM casodex and 10-nM DHT. The adjacent heatmap shows the PSI across different conditions including LNCaP cells treated with DHT or enzalutamide. b Functional validation for the casodex-mediated switch in the IDH1 isoform expression. The box plot comparing the expression of the ENST00000345146 or ENST00000415913 between TCGA-prostate adenocarcinoma tissue and GTEX-normal prostate tissue. The Kaplan–Meier plot displays the association between expression of ENST00000345146 and survival for patients with prostate cancer. c A dot plot comparing GO pathways enriched in differentially expressed or alternatively spliced genes modulated by casodex and DHT. d A bar plot showing GO pathways enriched in genes modulated by enzalutamide in comparison to DHT.