Table 3.
Results from conditional analyses at previously reported smoking behaviour loci
| Gene region | dbSNP ID | Chr:Pos | EA/OA | Consequence | Trait | EAF | P (unconditional) | SNV(s) conditioned on | Discovery Conditional P [DoE] | Conditional P in replication [DoE] |
|---|---|---|---|---|---|---|---|---|---|---|
| 19q13 (RAB4B) | rs8102683 | 19:41363765 | C/T | Intergenic | CPD | 74.8% | 4.53 × 10−16 | rs7937 | 1.44 × 10−13 [+] | 3.5 × 10-4 [+] |
| rs28399442 | 19:41354458 | A/C | Intronic (CYP2A6) | CPD | 1.3% | 2.27 × 10−12 | rs7937, rs8102683 | 2.63 × 10−12 [+] | 8.1 × 10−14 [+] | |
| rs3865453 | 19:41338556 | T/C | Intergenic | CPD | 6.54% | 2.96 × 10−12 | rs7937, rs8102683, rs28399442 | 4.96 × 10−10 [−] | 2.3 × 10−13 [−] | |
| TEX41-PABPC1P2 | rs11694518 | 2:146125523 | T/C | Intergenic | SI | 29.5% | 2.90 × 10−9 | rs10193706 | 3.43 × 10−7 [−] | 4.0 × 10−31 [−] |
| 15q25 (CHRNA3) | rs938682 | 15:78882925 | A/G | Intronic (CHRNA3) | CPD | 76.4% | 1.83 × 10−69 | rs1051730 | 7.77 × 10−21 [+] | 1.0 × 10−13 [+] |
SNVs with P < 5 × 10−8 are highlighted in bold. The discovery sample size for smoking initiation (SI) and CPD was 346,813 and 128,746, respectively. The replication sample size for SI and CPD were 275,596 and 80,015, respectively. Chr Chromosome, Pos position for hg19 build 37, EA effect allele, OA other allele, EAF effect allele frequency in the pooled samples, DoE Direction of effect