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. 2019 Oct 7;25(10):2455–2467. doi: 10.1038/s41380-019-0517-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Trans-ancestry association of polygenic risk scores with schizophrenia. For scores based on PGC-SCZ2, GPC-AA or GPC-Latino, and meta-analysis results, the variance in risk explained in the other study is shown on the y-axis in terms of R² on the liability scale. a Scores based on various P value inclusion thresholds are displayed as shaded bars; b scores based on P_T < 0.5 and varying pairwise LD between SNPs are displayed as shaded bars. Analyses of PGC-SCZ2 and meta-analysis scores utilized an independent cohort of European ancestry GPC participants