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. 2018 Oct 3;25(10):2295–2312. doi: 10.1038/s41380-018-0263-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, b Types of genetic variants mapped by SNP sets associated with character: a Specific molecular consequences (Supplementary Table S5) and b their subtypes. Genes related only to character sets (red) were less often protein coding and more often RNA genes than those also associated with temperament sets (blue color). c Cell displaying the molecular pathways containing genes associated only with the organized profile. The uncovered genes influence the phosphatidyl inositol/calcium second-messenger signaling system that regulates the seeking of food and other goals in response to external environmental signals (see also Supplementary Tables S4, S7). d Multiple SNPs within a SNP set can affect a single or multiple genes in many ways (Supplementary Table S3). Within the MTA3 gene, SNPs in the SNP set G_12_1 may affect both coding and regulatory regions (thereby inhibiting transcription), whereas SNPs from SNP set 40_26 are mostly located in intronic regions (thereby blocking or decreasing protein production). The SNP sets are associated with profiles exhibiting distinct character features (creative vs. apathetic)