Table 1.
Description of 42 SNP sets associated with character sets (p < 1E-05)
| Finnish sample | Probability of health | aGenes | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| SNP sets | SNP-set name | % Coding | SKAT p-value | Best SNP | Average SNPs | aSubjects | aSNPs | Well-being | Ill-being | |
| G_3_1 | Inositol-calcium signaling* | 62 | 2.88E-102 | 3.01E-05 | 2.64E-01 | 311 | 2163 | 0.06 | 0.1 | >300 |
| G_8_8 | Inositol/chemokine pathways | 67 | 2.21E-55 | 8.55E-05 | 1.99E-01 | 224 | 611 | 0.08 | 0.07 | 291 |
| G_7_2 | GPCR dysregulation | 62 | 2.07E-31 | 9.00E-05 | 2.44E-01 | 211 | 303 | 0.09 | 0.23 | 142 |
| G_7_3 | Neurogenesis | 63 | 1.67E-20 | 1.07E-04 | 1.85E-01 | 133 | 364 | 0.17 | 0.36 | 136 |
| G_11_4 | Inositol signaling | 55 | 1.22E-19 | 9.00E-05 | 3.29E-02 | 141 | 172 | 0.07 | 0.04 | 51 |
| G_12_8 | Neuroprotection | 62 | 1.49E-16 | 2.53E-04 | 3.39E-01 | 173 | 285 | 0.09 | 0.03 | 111 |
| G_7_7 | Olfaction | 56 | 1.32E-11 | 3.27E-05 | 2.25E-01 | 145 | 193 | 0.03 | 0.1 | 55 |
| G_36_29 | Electron transport | 50 | 5.37E-09 | 4.27E-04 | 3.37E-01 | 25 | 185 | 0.08 | 0.48 | 76 |
| G_31_8 | Neurotrophin | 55 | 1.15E-08 | 2.90E-05 | 3.13E-01 | 54 | 183 | 0.09 | 0.54 | 64 |
| G_28_15 | Histone methylation | 44 | 2.77E-08 | 3.76E-05 | 2.23E-01 | 101 | 123 | 0.08 | 0.38 | 34 |
| G_9_8 | Neuroregulation | 57 | 3.82E-08 | 1.11E-04 | 3.48E-01 | 209 | 230 | 0.17 | 0.12 | 77 |
| G_24_6 | GFI1-neurite outgrowth | 36 | 5.22E-08 | 2.65E-04 | 7.47E-02 | 72 | 63 | 0.1 | 0.08 | 14 |
| G_19_5 | DARPP320-neuroplasticity | 30 | 8.31E-08 | 1.23E-04 | 2.13E-01 | 86 | 59 | 0.16 | 0.22 | 10 |
| G_33_15 | ERK-neurodevelopment | 53 | 1.60E-07 | 4.47E-04 | 8.47E-02 | 26 | 67 | 0.27 | 0.23 | 19 |
| G_23_2 | Biogenic amine synthesis | 50 | 2.24E-07 | 1.39E-04 | 9.46E-02 | 42 | 56 | 0.05 | 0.29 | 8 |
| G_3_2 | PAK-neuroprotection | 63 | 3.08E-07 | 1.70E-05 | 1.80E-01 | 133 | 197 | 0.18 | 0.24 | 35 |
| G_22_6 | Blood–brain barrier | 59 | 3.37E-07 | 2.53E-04 | 2.35E-01 | 37 | 93 | 0.08 | 0.16 | 32 |
| G_34_13 | CREB-episodic learning | 54 | 3.88E-07 | 2.38E-04 | 1.28E-01 | 41 | 49 | 0.05 | 0.29 | 13 |
| G_40_26 | Dopamine-feedback | 65 | 6.08E-07 | 3.88E-04 | 2.61E-01 | 39 | 98 | 0.08 | 0.36 | 17 |
| G_21_3 | Cellular senescence | 62 | 1.12E-06 | 1.85E-04 | 3.55E-01 | 60 | 117 | 0.1 | 0.23 | 34 |
| G_20_2 | Enhanced memory | 79 | 1.59E-06 | 2.78E-04 | 2.34E-01 | 25 | 80 | 0.24 | 0.12 | 19 |
| G_28_11 | Sensory transduction | 44 | 2.07E-06 | 8.29E-04 | 2.71E-01 | 32 | 81 | 0.22 | 0.06 | 9 |
| G_12_1 | Episodic learning | 61 | 5.06E-06 | 9.00E-05 | 3.41E-01 | 146 | 189 | 0.2 | 0.06 | 66 |
| G_41_33 | GPCR neuroplasticity | 40 | 5.31E-06 | 4.91E-04 | 2.71E-01 | 56 | 76 | 0.11 | 0.21 | 15 |
| G_9_3 | Pyrimidine metabolism | 50 | 6.03E-06 | 4.54E-05 | 2.55E-02 | 164 | 35 | 0.12 | 0.04 | 6 |
| G_26_14 | Glucose transport | 59 | 6.98E-06 | 1.08E-04 | 2.20E-01 | 46 | 75 | 0.09 | 0.24 | 27 |
| G_20_3 | Fatty acid oxidation | 48 | 8.03E-06 | 2.07E-04 | 3.04E-01 | 36 | 82 | 0.03 | 0.33 | 21 |
| G_23_19 | Org2-RNA | 0 | 1.17E-05 | 3.76E-05 | 9.37E-04 | 87 | 32 | 0.08 | 0.03 | 4 |
| G_17_14 | Dep-RNA | 0 | 1.17E-05 | 3.76E-05 | 9.37E-04 | 47 | 32 | 0.09 | 0.15 | 4 |
| G_27_25 | Org3-RNA | 0 | 1.17E-05 | 3.76E-05 | 9.37E-04 | 54 | 32 | 0.11 | 0.07 | 4 |
| G_41_40 | Apath-RNA | 0 | 1.17E-05 | 3.76E-05 | 9.37E-04 | 34 | 32 | 0.09 | 0.03 | 4 |
| G_38_10 | Org5-RNA | 0 | 1.17E-05 | 3.76E-05 | 9.37E-04 | 27 | 32 | 0.15 | 0.19 | 4 |
| G_33_19 | Res-RNA | 0 | 1.17E-05 | 3.76E-05 | 9.37E-04 | 43 | 32 | 0.09 | 0.12 | 4 |
| G_21_4 | Org1-RNA | 0 | 1.28E-05 | 3.76E-05 | 9.41E-02 | 68 | 43 | 0.07 | 0.07 | 4 |
| G_10_1 | Learning/memory | 47 | 1.29E-05 | 3.27E-05 | 7.44E-02 | 131 | 48 | 0.07 | 0.06 | 15 |
| G_35_12 | Org4-RNA | 0 | 1.33E-05 | 3.76E-05 | 9.32E-04 | 45 | 31 | 0.16 | 0.09 | 3 |
| G_35_4 | O-linked glycosylation | 57 | 1.39E-05 | 3.74E-04 | 2.83E-01 | 42 | 37 | 0.05 | 0.24 | 7 |
| G_5_1 | CDK neuroplasticity | 100 | 1.78E-05 | 1.70E-05 | 5.60E-02 | 100 | 91 | 0.17 | 0.4 | 1 |
| G_19_9 | Aurora-B | 38 | 1.91E-05 | 2.65E-04 | 1.25E-01 | 20 | 46 | 0.1 | 0.4 | 8 |
| G_36_27 | Aging regulation | 25 | 1.96E-05 | 8.29E-04 | 1.60E-01 | 27 | 57 | 0.33 | 0.22 | 4 |
| G_16_9 | Olfactory signaling | 58 | 2.00E-05 | 2.31E-04 | 1.79E-01 | 64 | 36 | 0.08 | 0.17 | 12 |
| G_33_11 | Self-control | 50 | 3.67E-05 | 2.65E-04 | 9.39E-02 | 43 | 32 | 0.26 | 0.07 | 15 |
The SNP sets are named based on molecular pathways and neuronal functions of the genes that distinguish the sets from one another (see Supplementary Table S4). Percentage coding indicates the percentage of protein coding genes. Strengths of association are compared for the SNP set, the best SNP, and average SNP based on SKAT p-values. The number of subjects and SNPs comprising each SNP set is specified. The probabilities of the well-being and ill-being are given for subjects in each SNP set (see also Supplementary Table S2)
aGenes indicates the genes mapped by the SNP set (Figure S6), where genes can be mapped by more than one SNP set