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. 2018 Oct 3;25(10):2295–2312. doi: 10.1038/s41380-018-0263-6

Table 3.

The strength of the genotypic–phenotypic relationships among SNP and character sets and their corresponding health measurements

Character sets Character consensus sets SNP sets SNP-set names Hypergeo-metric C-G Health measurements of subjects
Char sets SNP sets Both Sets Jointly
Well-being Ill-being Well-being Ill-being Well-being Ill-being
C_14_8 Resourceful G_12_8 Neuroprotection 1.29E-03 0.01 0.01 0.09 0.03 0.09 0.03
C_10_7 Resourceful G_12_8 Neuroprotection 2.79E-03 0.41 0 0.09 0.03 0.41 0.03
C_10_7 Resourceful G_33_11 Self-control 3.68E-03 0.41 0 0.26 0.07 0.41 0.07
C_10_6i Resourceful G_33_19 Res-RNA 4.33E-03 0.03 0.38 0.09 0.12 0.09 0.38
C_14_8 Resourceful G_11_4 Inositol signaling 4.86E-03 0.01 0.01 0.07 0.04 0.07 0.04
C_4_4 Organized G_11_4 Inositol signaling 1.26E-11 0.01 0 0.07 0.04 0.07 0.04
C_3_1 Organized G_11_4 Inositol signaling 7.18E-09 0 0 0.07 0.04 0.07 0.04
C_5_1 Organized G_11_4 Inositol signaling 2.19E-06 0.05 0 0.07 0.04 0.07 0.04
C_4_4 Organized G_12_8 Neuroprotection 9.79E-06 0.01 0 0.09 0.03 0.09 0.03
C_3_1 Organized G_12_8 Neuroprotection 1.38E-05 0 0 0.09 0.03 0.09 0.03
C_8_7 Organized G_11_4 Inositol signaling 2.78E-05 0.04 0 0.07 0.04 0.07 0.04
C_4_4 Organized G_10_1 Learning/memory 4.79E-05 0.01 0 0.07 0.06 0.07 0.06
C_3_1 Organized G_10_1 Learning/memory 9.45E-05 0 0 0.07 0.06 0.07 0.06
C_3_1 Organized G_21_4 Org1-RNA 1.70E-04 0 0 0.07 0.07 0.07 0.07
C_4_4 Organized G_8_8 Global inositol/chemokine pathways 1.86E-04 0.01 0 0.08 0.07 0.08 0.07
C_14_13 Organized G_24_6 Neurogenesis 1.86E-04 0.09 0 0.1 0.08 0.1 0.08
C_4_4 Organized G_3_1 Inositol calcium signaling 3.38E-04 0.01 0 0.06 0.1 0.06 0.1
C_9_8 Organized G_12_8 Neuroprotection 4.62E-04 0.12 0 0.09 0.03 0.12 0.03
C_3_1 Organized G_3_1 Inositol calcium signaling 7.05E-04 0 0 0.06 0.1 0.06 0.1
C_7_7 Organized G_11_4 Inositol signaling 7.17E-04 0.07 0 0.07 0.04 0.07 0.04
C_5_1 Organized G_12_8 Neuroprotection 7.58E-04 0.05 0 0.09 0.03 0.09 0.03
C_14_13 Organized G_12_8 Neuroprotection 8.50E-04 0.09 0 0.09 0.03 0.09 0.03
C_14_13 Organized G_23_19 Org2-RNA 1.00E-03 0.09 0 0.08 0.03 0.09 0.03
C_5_1 Organized G_10_1 Learning/memory 1.09E-03 0.05 0 0.07 0.06 0.07 0.06
C_3_1 Organized G_8_8 Global inositol/chemokine pathways 1.12E-03 0 0 0.08 0.07 0.08 0.07
C_7_7 Organized G_17_14 Dep-RNA 1.32E-03 0.07 0 0.09 0.15 0.09 0.15
C_15_1i Organized G_36_29 Electron transport 1.66E-03 0 0.79 0.08 0.48 0.08 0.79
C_5_1 Organized G_8_8 Global inositol/chemokine pathways 2.07E-03 0.05 0 0.08 0.07 0.08 0.07
C_14_13 Organized G_11_4 Inositol signaling 2.33E-03 0.09 0 0.07 0.04 0.09 0.04
C_9_1i Organized G_38_10 Org5-RNA 2.34E-03 0 0.02 0.15 0.19 0.15 0.19
C_7_5i Organized G_35_12 Org4-RNA 2.43E-03 0.5 0.06 0.16 0.09 0.5 0.09
C_7_7 Organized G_12_8 Neuroprotection 2.50E-03 0.07 0 0.09 0.03 0.09 0.03
C_5_1 Organized G_17_14 Dep-RNA 3.00E-03 0.05 0 0.09 0.15 0.09 0.15
C_6_5 Organized G_11_4 Inositol signaling 3.04E-03 0.07 0 0.07 0.04 0.07 0.04
C_12_9 Organized G_7_3 Neurogenesis 3.13E-03 0.54 0 0.17 0.36 0.54 0.36
C_8_7 Organized G_10_1 Learning/memory 3.54E-03 0.04 0 0.07 0.06 0.07 0.06
C_4_4 Organized G_24_6 Neurogenesis 3.63E-03 0.01 0 0.1 0.08 0.1 0.08
C_14_9 Organized G_31_8 Neurotrophin 3.65E-03 0.02 0.29 0.09 0.54 0.09 0.54
C_14_9 Organized G_7_3 Neurogenesis 3.66E-03 0.02 0.29 0.17 0.36 0.17 0.36
C_9_6 Organized G_27_25 Org3-RNA 3.84E-03 0.11 0.02 0.11 0.07 0.11 0.07
C_8_7 Organized G_8_8 Global inositol/chemokine pathways 3.99E-03 0.04 0 0.08 0.07 0.08 0.07
C_12_9 Organized G_9_8 Neuroregulation 4.96E-03 0.54 0 0.17 0.12 0.54 0.12
C_3_3 Creative G_7_3 Neurogenesis 1.22E-06 0.92 0 0.17 0.36 0.92 0.36
C_3_3 Creative G_5_1 CDK neuroplasticity 2.00E-06 0.92 0 0.17 0.4 0.92 0.4
C_15_5 Creative G_3_2 PAK-neuroprotection 6.63E-06 0.72 0.03 0.18 0.24 0.72 0.24
C_4_3 Creative G_20_2 Enhanced memory 1.13E-05 0.97 0 0.24 0.12 0.97 0.12
C_14_1 Creative G_7_3 Neurogenesis 2.80E-05 0.25 0.11 0.17 0.36 0.25 0.36
C_11_3 Creative G_33_15 ERK-neurodevelopment 3.99E-05 0.97 0.03 0.27 0.23 0.97 0.23
C_8_8 Creative G_20_2 Enhanced memory 6.49E-05 1 0 0.24 0.12 1 0.12
C_3_3 Creative G_20_2 Enhanced memory 9.26E-05 0.92 0 0.24 0.12 0.92 0.12
C_5_5 Creative G_20_2 Enhanced memory 1.41E-04 1 0 0.24 0.12 1 0.12
C_4_3 Creative G_33_15 ERK-neurodevelopment 1.65E-04 0.97 0 0.27 0.23 0.97 0.23
C_5_5 Creative G_33_15 ERK-neurodevelopment 1.78E-04 1 0 0.27 0.23 1 0.23
C_12_7 Creative G_33_15 ERK-neurodevelopment 3.21E-04 0.9 0.04 0.27 0.23 0.9 0.23
C_4_3 Creative G_7_3 Neurogenesis 3.65E-04 0.97 0 0.17 0.36 0.97 0.36
C_5_5 Creative G_7_3 Neurogenesis 4.21E-04 1 0 0.17 0.36 1 0.36
C_6_1 Creative G_33_15 ERK-neurodevelopment 5.02E-04 1 0 0.27 0.23 1 0.23
C_5_5 Creative G_19_5 DARPP320-Neuroplasticity 5.30E-04 1 0 0.16 0.22 1 0.22
C_3_3 Creative G_19_5 DARPP320-neuroplasticity 7.66E-04 0.92 0 0.16 0.22 0.92 0.22
C_3_3 Creative G_33_15 ERK-neurodevelopment 8.46E-04 0.92 0 0.27 0.23 0.92 0.23
C_4_3 Creative G_12_1 Episodic learning 9.12E-04 0.97 0 0.2 0.06 0.97 0.06
C_7_2 Creative G_33_15 ERK-Neurodevelopment 9.82E-04 0.98 0 0.27 0.23 0.98 0.23
C_7_2 Creative G_36_27 Aging regulation 1.18E-03 0.98 0 0.33 0.22 0.98 0.22
C_13_1 Creative G_20_2 Enhanced memory 1.23E-03 0.9 0.02 0.24 0.12 0.9 0.12
C_13_1 Creative G_33_15 ERK-neurodevelopment 1.44E-03 0.9 0.02 0.27 0.23 0.9 0.23
C_3_3 Creative G_12_1 Episodic learning 1.59E-03 0.92 0 0.2 0.06 0.92 0.06
C_12_7 Creative G_12_1 Episodic learning 2.21E-03 0.9 0.04 0.2 0.06 0.9 0.06
C_3_3 Creative G_9_8 Neuroregulation 2.27E-03 0.92 0 0.17 0.12 0.92 0.12
C_3_3 Creative G_28_11 Sensory transduction 3.14E-03 0.92 0 0.22 0.06 0.92 0.06
C_13_1 Creative G_28_11 Sensory transduction 3.17E-03 0.9 0.02 0.22 0.06 0.9 0.06
C_4_3 Creative G_9_8 Neuroregulation 3.32E-03 0.97 0 0.17 0.12 0.97 0.12
C_5_5 Creative G_12_1 Episodic learning 3.32E-03 1 0 0.2 0.06 1 0.06
C_9_2i Creative G_34_13 CREB-Episodic learning 4.05E-03 0.05 0.2 0.05 0.29 0.05 0.29
C_12_7 Creative G_7_3 Neurogenesis 4.10E-03 0.9 0.04 0.17 0.36 0.9 0.36
C_12_7 Creative G_19_5 DARPP320-Neuroplasticity 4.22E-03 0.9 0.04 0.16 0.22 0.9 0.22
C_11_3 Creative G_9_8 Neuroregulation 4.24E-03 0.97 0.03 0.17 0.12 0.97 0.12
C_15_7 Dependent G_11_4 Inositol signaling 1.80E-06 0.03 0.02 0.07 0.04 0.07 0.04
C_12_6 Dependent G_31_8 Neurotrophin 8.93E-06 0.09 0.41 0.09 0.54 0.09 0.54
C_12_6 Dependent G_41_33 GPCR neuroplasticity 1.18E-05 0.09 0.41 0.11 0.21 0.11 0.41
C_15_13 Dependent G_31_8 Neurotrophin 6.14E-05 0 0.79 0.09 0.54 0.09 0.79
C_4_2 Dependent G_28_15 Histone methylation 6.90E-05 0 0.45 0.08 0.38 0.08 0.45
C_9_5 Dependent G_7_2 GPCR dysregulation 1.01E-04 0 0.26 0.09 0.23 0.09 0.26
C_15_7 Dependent G_8_8 Global inositol/chemokine pathways 2.03E-04 0.03 0.02 0.08 0.07 0.08 0.07
C_15_13 Dependent G_28_15 Histone methylation 2.92E-04 0 0.79 0.08 0.38 0.08 0.79
C_4_2 Dependent G_5_1 CDK neuroplasticity 3.98E-04 0 0.45 0.17 0.4 0.17 0.45
C_14_5 Dependent G_7_7 Olfaction 8.92E-04 0 0.29 0.03 0.1 0.03 0.29
C_15_7 Dependent G_17_14 Dep-RNA 1.01E-03 0.03 0.02 0.09 0.15 0.09 0.15
C_6_3 Dependent G_17_14 Dep-RNA 1.09E-03 0 0.32 0.09 0.15 0.09 0.32
C_12_6 Dependent G_7_3 Neurogenesis 1.21E-03 0.09 0.41 0.17 0.36 0.17 0.41
C_5_3 Dependent G_5_1 CDK neuroplasticity 1.43E-03 0.02 0.29 0.17 0.4 0.17 0.4
C_15_13 Dependent G_5_1 CDK neuroplasticity 1.83E-03 0 0.79 0.17 0.4 0.17 0.79
C_5_3 Dependent G_7_3 Neurogenesis 2.32E-03 0.02 0.29 0.17 0.36 0.17 0.36
C_9_5 Dependent G_5_1 CDK neuroplasticity 2.63E-03 0 0.26 0.17 0.4 0.17 0.4
C_4_2 Dependent G_7_3 Neurogenesis 2.66E-03 0 0.45 0.17 0.36 0.17 0.45
C_6_3 Dependent G_7_7 Olfaction 2.73E-03 0 0.32 0.03 0.1 0.03 0.32
C_4_2 Dependent G_31_8 Neurotrophin 2.93E-03 0 0.45 0.09 0.54 0.09 0.54
C_6_3 Dependent G_22_6 Blood-brain barrier 3.40E-03 0 0.32 0.08 0.16 0.08 0.32
C_4_2 Dependent G_41_33 GPCR neuroplasticity 3.44E-03 0 0.45 0.11 0.21 0.11 0.45
C_7_4 Dependent G_5_1 CDK neuroplasticity 3.56E-03 0 0.74 0.17 0.4 0.17 0.74
C_14_5 Dependent G_28_15 Histone methylation 3.73E-03 0 0.29 0.08 0.38 0.08 0.38
C_3_2 Apathetic G_5_1 CDK neuroplasticity 6.13E-10 0 1 0.17 0.4 0.17 1
C_3_2 Apathetic G_7_3 Neurogenesis 4.61E-08 0 1 0.17 0.36 0.17 1
C_3_2 Apathetic G_28_15 Histone methylation 2.32E-05 0 1 0.08 0.38 0.08 1
C_9_3i Apathetic G_26_14 Glucose transport 3.12E-04 0 1 0.09 0.24 0.09 1
C_3_2 Apathetic G_7_2 GPCR dysregulation 4.18E-04 0 1 0.09 0.23 0.09 1
C_10_2 Apathetic G_11_4 Inositol signaling 4.25E-04 0.01 0 0.07 0.04 0.07 0.04
C_12_4i Apathetic G_35_4 O-linked glycosylation 4.30E-04 0.03 0.53 0.05 0.24 0.05 0.53
C_11_4 Apathetic G_16_9 Olfactory signaling 5.78E-04 0 0.28 0.08 0.17 0.08 0.28
C_7_3i Apathetic G_36_29 Electron transport 5.96E-04 0 1 0.08 0.48 0.08 1
C_10_8 Apathetic G_5_1 CDK neuroplasticity 6.43E-04 0 0.79 0.17 0.4 0.17 0.79
C_14_7i Apathetic G_36_29 Electron transport 7.85E-04 0 1 0.08 0.48 0.08 1
C_11_10i Apathetic G_36_29 Electron transport 8.39E-04 0.03 0.5 0.08 0.48 0.08 0.5
C_11_6i Apathetic G_20_3 Fatty acid oxidation 1.06E-03 0 0.71 0.03 0.33 0.03 0.71
C_10_8 Apathetic G_31_8 Neurotrophin 1.21E-03 0 0.79 0.09 0.54 0.09 0.79
C_15_15i Apathetic G_41_40 Apha-RNA 1.61E-03 0 0.3 0.09 0.03 0.09 0.3
C_14_11 Apathetic G_28_15 Histone methylation 2.13E-03 0 0.47 0.08 0.38 0.08 0.47
C_3_2 Apathetic G_40_26 Dopamine-feedback 2.41E-03 0 1 0.08 0.36 0.08 1
C_10_2 Apathetic G_9_3 Pyrimidine metabolism 2.60E-03 0.01 0 0.12 0.04 0.12 0.04
C_13_3i Apathetic G_26_14 Glucose transport 2.67E-03 0 0.25 0.09 0.24 0.09 0.25
C_8_6i Apathetic G_36_29 Electron transport 2.69E-03 0 1 0.08 0.48 0.08 1
C_10_8 Apathetic G_19_9 Aurora-B 3.25E-03 0 0.79 0.1 0.4 0.1 0.79
C_10_8 Apathetic G_7_3 Neurogenesis 3.47E-03 0 0.79 0.17 0.36 0.17 0.79
C_10_8 Apathetic G_23_2 Biogenic synthesis 3.56E-03 0 0.79 0.05 0.29 0.05 0.79
C_11_6i Apathetic G_36_29 Electron transport 3.88E-03 0 0.71 0.08 0.48 0.08 0.71
C_12_5 Apathetic G_7_2 GPCR dysregulation 3.99E-03 0 0.09 0.09 0.23 0.09 0.23
C_10_2 Apathetic G_10_1 Learning/memory 4.03E-03 0.01 0 0.07 0.06 0.07 0.06
C_8_3 Apathetic G_21_3 Cellular Senescence 4.17E-03 0 0.64 0.1 0.23 0.1 0.64
C_14_3i Apathetic G_26_14 Glucose transport 4.43E-03 0.06 0.38 0.09 0.24 0.09 0.38

Association is measured by Fisher's exact test (hypergeometric). Probabilities of well-being and ill-being are given for subjects in the character sets, the SNP sets, and subjects identified in both jointly. iIndicates character sets that are more specific than their parental sets, which are also selected