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. 2019 Oct 8;25(10):2313–2329. doi: 10.1038/s41380-019-0539-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Maternal inflammation causes large-scale impairment in the distribution of GAD-EGFP+ neuroblasts and mature interneurons in the cortex. a–c Graphs showing a decrease in density of EGFP+ cells measured by counting EGFP+ cells in ten equally sized bins in the cortical plate of the presumptive motor and somatosensory cortices. Dotted lines represent the margins of IZ, CP, and MZ, respectively (P3 motor: F = 21.85, P3 somatosensory: F = 24.1, n = 8, 7 for PBS and poly I:C respectively; P6 motor: F = 21.72, P6 somatosensory: F = 19.59, n = 8, 8 for PBS and poly I:C respectively; P9 motor: F = 12.22, and P9 somatosensory: F = 13.77, n = 8, 10 for PBS and poly I:C respectively). d–h Significant reduction in the density of interneurons in the somatosensory but not in the motor cortex at P15. EGFP+ cells were quantified in the total cortical thickness as well as in each cortical layer. Panels in d show representative images of regions used for quantification. Graphs show the total (e, f) (n = 8 and 7 for PBS and poly I:C, respectively) as well as the layer-wise (g, h) reduction in EGFP+ cell density. Comparison of means by two-way ANOVA in a–c, Student’s t-test in e and f, and t-test with Holm–Sidak correction for multiple comparison in g and h) (mean ± SEM are shown, ***p < 0.0005). Scale bars: 50 µm (d)