Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Aug 2;57(11):4467–4487. doi: 10.1007/s12035-020-02042-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 6 — In situ colocalization of TSPO with gp91^phox in murine brain microglia. a Representative triple labeled immunofluorescent confocal images in the thalamus of a 2-month old Sandhoff disease mouse at 60× with 1.6× zoom. Imaging confirmed that the TSPO signal colocalizes with the gp91^phox signal in Mac-1 labeled microglia. b Quantification of percent colocalization of TSPO with gp91^phox in microglia in the thalamus of Sandhoff disease mice compared to wildtype as a function of age. The data indicates that the TSPO-gp91^phox interaction increases as a function of age and progression of neurological disease (age: F_3,7 = 4.257, p = 0.017; genotype: F_1,7 = 11.081, p = 0.003; age × genotype: F_3,7 = 1.548, p = 0.232). Data are expressed as mean ± s.e.m. n = 4 independent animals and experiments per group, except for the 2-month old wildtype group which has n = 3 due to one animal being excluded as an outlier (> 3 standard deviations from the mean)