Table 3.
Metabolite variation observed in the models established within the training set.
| Model 1 | Model 2 | ||||
|---|---|---|---|---|---|
| CN–ADa | CN–MCIa | ||||
| CN | Metabolite | AD | CN | Metabolite | MCI |
| Gln | ↑ | Glc, Gln, Ile, Leu, Tyr, Val | ↑ | ||
| ↑ | Ace, Cho, Ile, Leu, Val | ↑ | Ace, Lac, Glu, His, Lys | ||
| Model 3 | Model 4 | ||||
|---|---|---|---|---|---|
| SMD–ADa | MCI–ADa | ||||
| SMD | Metabolite | AD | MCI | Metabolite | AD |
| Ace, Cho, MeOH, Pc/Gpc | ↑ | Glc, Glyceryl lipids, Lac | ↑ | ||
| ↑ | uFA, sFA, Glc | ↑ | Ala, Ile, Leu, Val | ||
aUpward arrows indicate a higher concentration of the metabolites in the corresponding class with respect to the other one. Metabolites in bold present VIP > 1 and |pcorr|≥ ± 0.6. Ace, acetate; Ala, alanine; Cho, choline; Glc, glucose; Gln, glutamine; Glu, glutamate; Gpc, glycerolphosphocholine; His, histidine; Ile, isoleucine; Lac, lactate; Leu, leucine; Lys, lysine; MeOH, methanol; Pc, phosphocholine; sFA, saturated fatty acids; Tyr, tyrosine; uFA, unsaturated fatty acids; Val, valine.