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. 2020 Sep 24;10:15644. doi: 10.1038/s41598-020-72654-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Graph shows the lipid classes detected in the plasma of patients with PPMS and healthy controls. Neutral and polar lipids were measured, and then classified based on their main biological function: storage, signalling, metabolism product, and membrane lipids. 1,068 lipid species, belonging to 15 different lipid classes, were detected in the plasma of PPMS patients. In bold-italic is indicated the name of the lipid class and in round brackets its abbreviation. In square brackets is indicated the total number of lipids detected per each class. Up-facing and down-facing arrows indicates fold-change (PPMS/controls) trends of increased or decreased lipid levels respectively.