Table 3.
MRI metrics at baseline and follow-up.
| PPMS | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| PPMS | PPMS-NP | PPMS-P | |||||||
| Baseline | 1-Y FU | p-valuea | Baseline | 1-Y FU | p-valuea | Baseline | 1-Y FU | p-valuea | |
| T1 lesion |
3.31 (± 5.41) |
3.92 (± 6.61) |
0.005 |
3.51 (± 6.68 |
4.49 (± 8.55) |
0.015 |
3.08 (± 3.93) |
3.27 (± 3.91) |
0.139 |
| T2 lesion |
5.71 (± 7.79) |
6.43 (± 8.55) |
0.087 |
5.89 (± 9.62) |
6.75 (± 10.15) |
0.139 |
5.50 (± 5.68) |
6.06 (± 6.94) |
0.314 |
| CblV |
114.63 (± 13.16) |
112.02 (± 12.62) |
< 0.001 |
110.33 (± 14.57) |
108.67 (± 14.77) |
0.005 |
119.40 (± 10.12) |
115.74 (± 9.15) |
0.008 |
| CblGMV |
86.85 (± 9.33) |
85.07 (± 8.62) |
< 0.001 |
83.42 (± 9.35) |
82.54 (± 9.29) |
0.013 |
90.67 (± 8.13) |
87.88 (± 7.28) |
0.008 |
| CblWMV |
27.77 (± 5.48) |
26.95 (± 5.36) |
< 0.001 |
26.91 (± 6.66) |
26.14 (± 6.56) |
0.017 |
28.72 (± 3.98) |
27.85 (± 3.80) |
0.008 |
Statistically significant differences between groups (p < 0.05) are highlighted in bold.
aWilcoxon signed rank test.
1-Y FU = 1-year follow-up; CblV, cerebellar volume; CblGMV, cerebellar grey matter volume; CblWMV, cerebellar white matter volume. All values are expressed in mL. Values represent mean (± SD).