. 2020 Sep 24;10:15652. doi: 10.1038/s41598-020-72567-6

Table 2.

Age prediction performances of the different statistical models on the training and testing sets.

Model	Best performance from Training (T)/Testing (V) sets^a	Number of CpGs	CpG combination	Training set			Testing set
Model	Best performance from Training (T)/Testing (V) sets^a	Number of CpGs	CpG combination	R	MAD	RMSE	R	MAD	RMSE
Zbiec-Pierkarska 1	–	2	CpG_5,7	0.918	6.885	9.127	0.932	6.397	8.803
MQR	T	9	CpG_{1–2 & 4–6} & CpG₂²_,4²_,6²_–7²	0.945	5.133	6.975	0.950	4.773	6.730
MQR	V	8	CpG_4–6 & CpG₂²_–4²_,6²_–7²	0.941	5.229	7.184	0.953	4.574	6.559
SVM_r	T	6	CpG_1–3,5–7	0.956	4.555	6.229	0.953	4.464	6.544
SVM_r	V	5	CpG_2–3,5–7	0.9546	4.6139	6.3257	0.9534	4.4101	6.4919
SVM_l	T	7	CpG_1–7	0.935	5.575	7.531	0.943	5.221	7.194
SVM_l	V	5	CpG_2–6	0.930	5.650	7.793	0.945	5.130	7.058
SVM_p	T	7	CpG_1–7	0.799	9.946	13.046	0.830	9.734	12.124
SVM_p	V	5	CpG_3–7	0.778	10.456	13.582	0.833	9.465	12.098
GBR	T	7	CpG_1–7	0.992	1.993	2.627	0.953	4.549	6.520
GBR	V	5	CpG_2,4–7	0.989	2.378	3.121	0.955	4.426	6.398
mMDA	T	3	CpG_1,5–6	0.933	5.650	7.625	0.940	5.320	7.357
mMDA	V	3	CpG_2,5–6	0.929	5.801	7.855	0.943	5.231	7.223

^aFor each statistical model, both CpG combinations giving the best age prediction accuracy according to the training (T) and testing (V) sets were included in the table.