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. 2020 Sep 24;10:15629. doi: 10.1038/s41598-020-72024-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Direction of fold change of gene expression levels in AD vs. non-AD hippocampal samples compared with expression at 40 years vs. 8 post-conceptional weeks. The X-axis shows the 67 genes that are differentially expressed in the hippocampus of Alzheimer’s disease patients compared with the hippocampus of healthy subjects. The red bars on the Y-axis show the fold change of the differential expression of these genes in AD vs. non-AD hippocampal samples. The blue bars on the Y-axis show the fold change in the expression level of these genes in normal hippocampus at 40 years after birth (middle adulthood) compared with 8 weeks after conception (fetal life) in healthy humans.