Table 1.
Novel interactors of each of the cilia genes.
| Cilia gene | K | N | Novel interactors |
|---|---|---|---|
| AHI1 | 1 | 2 | ARFGEF3, IFNGR1 |
| AK7 | 0 | 3 | BEGAIN, C14orf177, SLC25A29 |
| ARL13B | 1 | 4 | MINA, CRYBG3, ARL6, DHFRL1 |
| ARMC4 | 3 | 3 | ARHGAP21, OTUD1, PIP4K2A |
| ATP8A2 | 1 | 3 | C1QTNF9B-AS1, WASF3, SACS |
| ATXN10 | 9 | 9 | TTLL12, RIBC2, SMC1B, GGA1, KCNH3, PIK3R2, KIAA0930, SAMM50, CERK |
| B9D1 | 7 | 3 | TNFRSF13B, USP22, GIT1 |
| B9D2 | 2 | 7 | PLEKHG2, YIF1B, CCDC97, CNFN, CEACAM21, ZNF574, CNTD2 |
| BBIP1 | 0 | 0 | None |
| BBS1 | 13 | 6 | ACTN3, BAK1, BAD, ATP6AP2, PEPD, POLR2G |
| BBS2 | 11 | 10 | APOC2, WRNIP1, CETP, GOT2, SPTSSA, CES1, CNOT1, HSF4, MAP2K5, KCNK17 |
| BBS4 | 13 | 5 | ANP32A, AAGAB, MRPL28, SEMA7A, IGDCC3 |
| BBS5 | 5 | 11 | SLC6A15, CCDC173, KLHL41, CTSK, COTL1, EIF4EBP3, UBR3, KLHL23, ORM2, PRDM2, HRH1 |
| BBS7 | 5 | 8 | ANXA5, PDE8B, MSH6, MAD2L1, TRPC3, NDNF, QRFPR, CNGA1 |
| BBS9 | 0 | 6 | NME8, CD33, EHMT2, TRGV9, FGF2, CAPN1 |
| CASC1 | 1 | 2 | GOLT1B, PYROXD1 |
| CBY1 | 8 | 3 | APOL2, BCR, SPTLC3 |
| CC2D2A | 0 | 3 | CPEB2, NCAPG, RAB28 |
| CCDC114 | 8 | 4 | CGB8, EXOC3L2, CGB7, CGB1 |
| CCDC135 | 6 | 0 | None |
| CCDC39 | 0 | 1 | TTC14 |
| CCDC40 | 1 | 3 | NARF, RPTOR, WDR45B |
| CCDC63 | 0 | 2 | ALKBH2, C12orf76 |
| CCDC65 | 0 | 3 | FAM186B, DNAJC22, RHEBL1 |
| CCNA1 | 32 | 7 | VDR, RFC3, GJB2, ZNF385A, PSMB9, SLC7A1, EDEM1 |
| CDK3 | 17 | 10 | CCDC47, CA4, ALG1, TLK2, ITIH4, PRKCA, PECAM1, NAP1L1, FOXJ1, TBX2 |
| CEP290 | 2 | 0 | None |
| CETN1 | 4 | 10 | ALDH7A1, CCNH, GABRE, MUL1, YES1, LGALS3, PTPRM, USP14, TPD52L2, PTAFR |
| CETN2 | 9 | 12 | ATP6AP1, C14orf166, ATP2B3, NUCB1, DKC1, PTPRN, CLIC2, DNASE1L1, TEX28, IL2RG, DDX3X, CORIN |
| CETN3 | 6 | 11 | ATP6AP1L, HSP90AB1, HOXD10, SGOL1, FABP4, HAPLN1, TNNT1, P3H1, DNAJC19, POLR3G, PRKD3 |
| CHMP5 | 14 | 6 | NUP98, UBAP1, DYNLL2, TMEM8B, DOPEY2, GPX3 |
| DAW1 | 2 | 1 | RAB25 |
| DDI2 | 0 | 3 | AADACL3, CELA2A, PRAMEF1 |
| DNAAF1 | 0 | 2 | LINC00311, KCNG4 |
| DNAAF2 | 1 | 4 | ATL1, TRIM9, L2HGDH, TMX1 |
| DNAAF3 | 0 | 7 | ACPT, BRSK1, SIGLEC14, SIGLEC12, LENG9, LILRA5, ZNF606 |
| DNAH1 | 0 | 7 | ABHD14A, SEPSECS, LIN7B, POC1A, RPP30, GNL3, G3BP1 |
| DNAH10 | 0 | 3 | GATC, RILPL2, TMEM120B |
| DNAH11 | 0 | 3 | CPVL, GGCT, IL6 |
| DNAH12 | 0 | 1 | PDE12 |
| DNAH14 | 1 | 6 | ACBD3, CNIH3, ENAH, TMEM63A, SDE2, MIXL1 |
| DNAH17 | 0 | 0 | None |
| DNAH2 | 0 | 6 | CDK18, CCDC42, KCTD11, ODF4, PIK3R6, KRBA2 |
| DNAH3 | 0 | 7 | ERI2, TCIRG1, SOD1, THUMPD1, NPIPB3, LOC81691, IVL |
| DNAH5 | 0 | 13 | CTNND2, CKB, CDH6, DAP, LARGE, MYO10, TLE1, MVP, RAN, TRIO, MARCH6, MICAL1, RBFOX2 |
| DNAH6 | 0 | 1 | PLGLB1 |
| DNAH7 | 2 | 9 | CSTF3, SHC1, STK17B, STAT4, METTL21A, TMEFF2, NABP1, TMEM194B, MIB2 |
| DNAH8 | 0 | 3 | TOMM6, RAB44, RASGRP1 |
| DNAH9 | 0 | 3 | YBX2, NLGN2, STX8 |
| DNAI1 | 2 | 6 | ATG10, CDKN2A, ZIC3, NPR2, METTL21B, GLDC |
| DNAI2 | 0 | 1 | MFSD11 |
| DNAJB1 | 28 | 10 | CYP4F3, ARR3, CEP72, ADGRL3, ELAVL3, DNM2, ILF3, LYL1, SH3BP1, SSTR2 |
| DNAJB13 | 0 | 4 | BDKRB1, ARFRP1, KLHL35, WISP1 |
| DNAL1 | 0 | 3 | CIPC, LIN52, SLIRP |
| DNAL4 | 9 | 9 | DDX17, CACNA1I, UBA7, TRIOBP, TOM1, GTPBP1, RHOT2, JOSD1, HMGXB4 |
| DNALI1 | 5 | 3 | GJA4, GJB5, TMEM200B |
| DRC1 | 1 | 4 | C2orf44, CENPO, C2orf16, TCF23 |
| DRC7 | 6 | 8 | CCDC102A, ADGRG5, CPNE2, C16orf70, ZNF319, USB1, NDUFB9, MT4 |
| DRD1 | 11 | 5 | AP3M1, PLCD1, RARS, PPP4C, KCNMB1 |
| DRD2 | 20 | 13 | CASP1, CCNA2, CD3G, CD3E, GPC6, SGSH, VWA5A, INPPL1, IL10RA, PSG7, NQO2, RBM22, E2F6 |
| DRD5 | 5 | 2 | NKX3-2, FGFBP2 |
| DYNLL1 | 76 | 5 | RFC5, SUDS3, GABRQ, WSB2, VSIG10 |
| DYNLL2 | 47 | 9 | C17orf67, CHMP5, C17orf47, HSF5, STXBP4, F13A1, KIF2B, PRKD3, MSI2 |
| DYNLRB1 | 6 | 2 | CBFB, PDRG1 |
| DYNLRB2 | 4 | 8 | WWOX, SDR42E1, TGFBI, ZNF134, SLC38A8, NECAB2, IRF2BPL, MPHOSPH6 |
| DYNLT1 | 28 | 7 | CRHBP, ACAT2, SYNJ2, RPS6KA2, TMEM143, PARK2, ERO1L |
| DYNLT3 | 7 | 4 | CYBB, IFITM1, UIMC1, FOS |
| DYX1C1 | 4 | 3 | GCOM1, PRTG, WDR72 |
| DZIP1L | 4 | 3 | PRR23B, NME9, PRR23C |
| EFHC1 | 6 | 2 | CENPQ, ADGRF4 |
| ESYT3 | 0 | 2 | FAIM, SLC35G2 |
| GALR2 | 1 | 1 | EIF4A3 |
| GALR3 | 0 | 4 | EIF3D, CEP72, ENTHD1, SUV420H1 |
| GAS8 | 0 | 7 | FANCA, COX7B, DPEP1, MYLIP, MVD, MC1R, TAF1C |
| GPR161 | 0 | 3 | C1orf112, TOR1AIP1, TBX19 |
| GPR83 | 0 | 12 | FUT4, CST1, CDK2AP1, AQP3, FGF13, PLSCR3, TYR, TPBG, JRKL, MRE11A, NINJ1, SPR |
| HEPH | 0 | 1 | MSN |
| HSPB11 | 2 | 4 | C1orf168, C1orf87, RPS26P15, PARS2 |
| HYDIN | 1 | 2 | FAM96B, CFDP1 |
| IFT122 | 1 | 2 | ZNF148, SLCO2A1 |
| IFT140 | 4 | 7 | DNAJA3, ZNF263, SLC9A3R2, RAB11FIP3, TELO2, IL32, TRAP1 |
| IFT172 | 2 | 4 | EFR3B, DNAJC27, RAB10, TMEM214 |
| IFT20 | 28 | 7 | ABHD15, COASY, HLCS, RALGPS2, RICTOR, TP53I13, RAB11FIP4 |
| IFT22 | 0 | 5 | C7orf43, NFE4, ORAI2, KMT2E, ZNF655 |
| IFT27 | 2 | 5 | DDX17, TNRC6B, KDELR3, TRIOBP, TAB1 |
| IFT43 | 2 | 3 | ELMSAN1, LIN52, NEK9 |
| IFT46 | 0 | 6 | NLRX1, TMPRSS4, SCN3B, TRAPPC4, SIDT2, PDZD3 |
| IFT52 | 1 | 2 | SPINT3, TOMM34 |
| IFT57 | 4 | 6 | CLTA, CASP8, CBLB, HTT, SLC25A3, TERT |
| IFT74 | 0 | 0 | None |
| IFT80 | 1 | 5 | FGFR4, OTOL1, SLITRK3, NMD3, ZBBX |
| IFT81 | 1 | 6 | ERP29, NAA25, TPCN1, SLC8B1, SDS, RPH3A |
| IFT88 | 6 | 6 | C1QTNF9B-AS1, ALDH8A1, MAP4K5, PDX1, TRIM24, SAP18 |
| INVS | 5 | 2 | ABCA1, TMEM245 |
| IQCB1 | 1 | 6 | CD80, UPK1B, TRH, LMOD1, PVRL3, TBL1X |
| LCA5 | 3 | 1 | FILIP1 |
| LOXHD1 | 0 | 4 | HDHD2, HAUS1, C18orf25, SKA1 |
| LRRC48 | 0 | 10 | ELAC2, GID4, EIF3E, FUNDC2, SMCR8, ZNF287, SPECC1, PLAGL1, ZNF624, SOD2 |
| LRRC56 | 0 | 2 | KRTAP5-1, MOB2 |
| LRRC6 | 2 | 1 | ST3GAL1 |
| MCHR1 | 2 | 8 | GRAP2, EP300, APOBEC3A, MASP2, EFCAB6, TCIRG1, MRPS18A, ST13 |
| MKS1 | 2 | 5 | ABCC3, DGKE, CACNA1G, RNF43, SMG8 |
| NEK8 | 4 | 0 | None |
| NME5 | 2 | 8 | HBEGF, APTX, MKRN1, IFITM1, VDAC1, SPOCK1, VIPR1, P4HA2 |
| NME8 | 1 | 2 | BBS9, SUGCT |
| NPHP1 | 15 | 2 | BCL2L11, COX5B |
| NPHP3 | 2 | 15 | CCDC50, ANAPC13, COL7A1, ASTE1, NAA50, DPP7, EPC1, DDX3Y, CDV3, DNAJC13, PIK3R4, TOPBP1, PARP14, PPP2R3A, RAB6B |
| NPHP4 | 1 | 6 | FBXO44, EDIL3, C1orf127, TMEM201, SCRG1, RBP7 |
| NPY2R | 4 | 3 | APOC3, ABCE1, SMAD1 |
| NPY5R | 4 | 2 | MDH2, KIF23 |
| PDCD6IP | 37 | 5 | ATG7, CLASP2, FBXL2, CRTAP, STAC |
| PIH1D1 | 31 | 5 | CABP5, C19orf73, RCN3, RASIP1, PRKG2 |
| PKD1 | 24 | 9 | NTHL1, NADSYN1, PDPK1, OR1F1, DDX58, NTN3, RPL3L, SOX17, PPL |
| PKD1L1 | 0 | 10 | C7orf69, ABCC3, C7orf65, ACAA2, C7orf57, MGAT2, ABCA13, RPL6, PLCB2, PSME3 |
| PKD2 | 14 | 6 | KIF11, ADH1C, MTAP, ADH1A, PPP3CA, UCHL3 |
| PKD2L1 | 3 | 6 | MYOF, HNRNPA2B1, LGI1, CAB39, GBF1, PRPS2 |
| PKHD1 | 1 | 7 | ORM1, CSTF2T, ILK, ATXN2, EML4, BAG2, PTGIS |
| PPIL6 | 0 | 2 | AK9, CEP57L1 |
| PPP1CB | 26 | 9 | NRBP1, DHX57, GCKR, NCOA1, MATN1, SRD5A2, UPK2, SH3KBP1, ZNF512 |
| PTCH1 | 65 | 5 | CORO2A, ECM2, DPP3, TMOD1, UFM1 |
| QRFPR | 0 | 9 | BBS12, BBS7, NDNF, EXOSC9, ADAD1, KIAA1109, TRPC3, TNIP3, TMEM155 |
| RABL5 | 0 | 0 | None |
| ROPN1L | 3 | 4 | FAM173B, 42435, CMBL, CCT5 |
| RPGR | 11 | 5 | NUDT12, ATP6AP2, USP9X, SLC9A7, TSPAN7 |
| RPGRIP1 | 23 | 1 | SLC6A2 |
| RPGRIP1L | 3 | 2 | CES1P1,SLC6A2 |
| RSPH1 | 1 | 7 | LINC01547, OSMR, COL18A1, LINC00313, LINC00334, LRRC3, UMODL1 |
| RSPH10B | 0 | 7 | DAGLB, CCZ1B, FOXK1, MMD2, RBAKDN, GRID2IP, SLC29A4 |
| RSPH3 | 5 | 6 | PNLDC1, MRPL18, RGS17, TAGAP, SERAC1, SYTL3 |
| RSPH4A | 0 | 6 | LACE1, HS3ST5, FAM26F, FLJ34503, FAM26E, ZUFSP |
| RSPH6A | 0 | 1 | SLC1A5 |
| RSPH9 | 2 | 9 | C6orf223, LRRC73, OARD1, KLHDC3, ADCY10P1, TSPO2, TCTE1, TAF8, SPATS1 |
| RTDR1 | 13 | 0 | None |
| SMO | 8 | 1 | LINC-PINT |
| SPAG1 | 3 | 7 | MME, NIPAL2, CPQ, POLR2K, RGS22, COL4A1, STK3 |
| SPAG16 | 2 | 1 | IKZF2 |
| SPAG17 | 0 | 2 | GDAP2, FAM46C |
| SPAG6 | 2 | 2 | OTUD1, PIP4K2A |
| SPEF2 | 0 | 10 | C5orf42, BRIX1, NIPBL, LMBRD2, DNAJC21, CAPSL, NADK2, UGT3A1, TARS, WDR70 |
| TCTE1 | 1 | 7 | KLC4, C6orf223, LRRC73, KLHDC3, SPATS1, TAF8, RSPH9 |
| TCTE3 | 1 | 4 | TCP10, LINC01558, RPS6KA2, RNASET2 |
| TCTN1 | 0 | 3 | GLTP, SVOP, FAM222A |
| TCTN2 | 0 | 3 | COQ5, KDM2B, CCDC92 |
| TCTN3 | 0 | 0 | None |
| TMEM17 | 0 | 3 | FAM161A, COMMD1, C2orf74 |
| TMEM216 | 1 | 9 | TEX40, SAC3D1, ATL3, EFEMP2, CABP2, CCDC87, SSH3, POLA2, TRMT112 |
| TMEM231 | 3 | 4 | TMEM170A, CNTNAP4, ADAT1, VAT1L |
| TMEM237 | 2 | 2 | ATP6V1C2, SFXN5 |
| TMEM30B | 0 | 4 | BCAR1, SLC38A6, C14orf37, NAA30 |
| TMEM67 | 1 | 4 | NDUFAF6, INTS8, FAM92A1, LAPTM4B |
| TRAF3IP1 | 27 | 3 | ATG4B, ANO7, SNED1 |
| TSG101 | 86 | 10 | PILRA, RPS13, MYLPF, DNAJB11, CALML5, ST5, PPP2R5D, MAPK15, ZNF160, ZNF419 |
| TTC21B | 0 | 4 | COBLL1, G6PC2, CSRNP3, CERS6 |
| TTC28 | 3 | 4 | GATSL3, TPST2, PES1, PITPNB |
| TTC30B | 0 | 7 | FKBP7, CCDC141, PLEKHA3, RBM45, HNRNPA3, SESTD1, TTC30A |
| TTC8 | 1 | 1 | PTPN21 |
| VPS28 | 27 | 7 | THEM6, CCNB1, OXCT1, OPLAH, RPL37A, SCRIB, CACNA1I |
| VPS37A | 7 | 4 | MICU3, CCAR2, COL11A2, KIAA1456 |
| VPS4B | 7 | 2 | SPHAR, PHLPP1 |
| WDR19 | 0 | 3 | NWD2, TLR10, CHRNA9 |
| WDR35 | 0 | 0 | None |
| WDR63 | 0 | 2 | RPL17P5, RPF1 |
| WDR78 | 0 | 1 | GNG12 |
| ZMYND10 | 10 | 2 | ACTR3, RALGDS |
| ZMYND12 | 0 | 3 | ERMAP, C1orf50, CABIN1 |
The table shows the number of known and computationally predicted novel PPIs for each of the 165 cilia genes, and lists their corresponding novel interactors.