Table 2.
Overlap of neuronal pathways in cilia interactome.
| Neuronal pathways in cilia interactome | p value | Number of proteins | Proteins |
|---|---|---|---|
| Huntington's disease signaling | 1.00E−13 | 15 | PLCB2,SHC1,CASP1,GNG12,PIK3R6,POLR2G,PIK3R4,CLTA,PIK3R2,CAPN1,PDPK1,RPH3A,CASP8,POLR2K,PRKD3 |
| Dopamine-DARPP32 feedback in cAMP Signaling | 2.00E−08 | 8 | PLCB2,PPP2R3A,PRKG2,CALML5,PLCD1,PPP2R5D,PPP3CA,PRKD3 |
| CREB signaling in neurons | 3.02E−08 | 11 | CALML5,PLCB2,SHC1,GNG12,PIK3R6,POLR2G,PIK3R4,PIK3R2,PLCD1,POLR2K,PRKD3 |
| nNOS signaling in neurons | 8.13E−06 | 4 | PPP3CA,CAPN1,CALML5,PRKD3 |
| nNOS signaling in neurons | 8.13E−06 | 4 | PPP3CA,CAPN1,CALML5,PRKD3 |
| Axonal guidance signaling | 8.91E−06 | 15 | PLCB2,GIT1,SHC1,PIK3R6,ACTR3,NTN3,GNG12,MICAL1,PIK3R4,MYLPF,PLCD1,PPP3CA,PRKD3,SEMA7A,PIK3R2 |
| eNOS signaling | 1.17E−05 | 13 | BDKRB1,CALML5,AQP3,CNGA1,CASP8,SLC7A1,HSP90AB1,PIK3R6,PIK3R4,PIK3R2,PDPK1,CHRNA9,PRKD3 |
| Synaptic long term potentiation | 1.26E−05 | 5 | PPP3CA,PLCB2,PRKD3,CALML5,PLCD1 |
| Wnt/Beta-catenin signaling | 1.62E−05 | 6 | CDKN2A,TLE1,PPP2R3A,ILK,SOX17,PPP2R5D |
| Neuregulin signaling | 3.63E−05 | 8 | SHC1,TMEFF2,HSP90AB1,HBEGF,BAD,PIK3R2,PDPK1,PRKD3 |
| Neuropathic pain signaling in dorsal horn neurons | 0.000224 | 7 | PLCB2,FOS,PIK3R6,PIK3R4,PIK3R2,PLCD1,PRKD3 |
| Calcium signaling | 0.000603 | 8 | TNNT1,SLC8B1,CABIN1,CALML5,TRPC3,PPP3CA,ATP2B3,CHRNA9 |
| Dopamine receptor signaling | 0.00251 | 3 | PPP2R5D,SPR,PPP2R3A |
| Glutamate receptor signaling | 0.00398 | 1 | CALML5 |
| Synaptic long term depression | 0.00676 | 7 | PLCB2,PPP2R3A,NPR2,PLCD1,PRKG2,PPP2R5D,PRKD3 |
| Wnt/Ca + pathway | 0.0102 | 3 | PPP3CA,PLCB2,PLCD1 |
| Dendritic cell maturation | 0.0102 | 12 | PLCB2,STAT4,COL11A2,COL18A1,CD80,TRGV9,IL6,PIK3R6,PIK3R4,IL32,PIK3R2,PLCD1 |
| Reelin signaling in neurons | 0.0407 | 3 | PIK3R6,PIK3R4,PIK3R2 |
Neuronal pathways which were present in cilia interactome with number of novel interactors.