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. 2020 Aug 5;57(11):4563–4577. doi: 10.1007/s12035-020-02045-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — The cell viability of MCF-7 cells after 72 h incubation of cisplatin (100 μM) or co-treatment of 10–400 μM LAT1-utilizing prodrug (PFI-PD) (light gray bars) or perforin inhibitor (PFI) (dark gray bars) together with 100 μM cisplatin. The data are presented as percentages (%) of the treatment groups compared with the untreated cells (ctrl) (mean ± SD, n = 3–6). An asterisk denotes a statistically significant difference from the respective control or the cisplatin-induced group (indicated with a separate line) (*** P < 0.001, one-way ANOVA, followed by Tukey’s test)