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. 2020 May 20;50(3):632–639. doi: 10.1007/s11239-020-02143-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Correlation of CoaguChek®-international normalized ratio (CC-INR) values and edoxaban plasma concentrations (dashed line: regression line), b changes in edoxaban plasma concentrations and CC-INR results over the course of the study period (displayed as mean ± one standard deviation), c percentage of edoxaban plasma concentrations below and above the treatment-relevant thresholds of 30 and 50 ng/mL found at different CC-INR levels, and d receiver operating characteristics curve found for CC-INR when testing for detection of samples containing edoxaban plasma concentrations ≤ 30 and ≤ 50 ng/mL