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Enhancing miR-21 or silencing STAT3 could suppress the IL-6 induced regulation of targeted genes. STAT3 signal transducers and activators of transcription 3, IL-6 interleukin-6, RASF rheumatoid arthritis fibroblast-like synovial cell, MMP matrix metalloproteinase, RANKL receptor activator of nuclear factor-κB ligand, NF-κb nuclear factor-κB
