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. 2020 May 13;109(10):1197–1222. doi: 10.1007/s00392-020-01636-7

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© The Author(s) 2020

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Fig. 1 — Interaction of genetic predisposition, classic risk factors and pre-existing cardiovascular diseases in the development or progression of a cardiovascular disease as a result of cancer therapy (‘2nd hit’) or the cancer itself. CAD coronary artery disease, PAD peripheral artery disease, LV left ventricular