Table 4.

Overview of novel haematological drugs, indications and the most common potential cardiac side effects from a clinical/cardiological perspective

Active ingredient group	Active ingredient	Currently approved for*	Potential cardiac side effects
Proteasome inhibitors	Bortezomib	Multiple myeloma	Heart failure
	Carfilzomib	Multiple myeloma	Heart failure
HDAC inhibitors	Vorinostat	Cutaneous T-cell lymphoma, multiple myeloma	QTc prolongation
	Panobinostat	Multiple myeloma	QTc prolongation
	Romidepsin		QTc prolongation
Immunomodulatory drugs	Lenalidomide	Multiple myeloma	Arterial venous thrombosis, arterial hypertension, heart failure
	Pomalidomide	Multiple myeloma	Arterial venous thrombosis

HDAC histone deacetylase

^*According to the EMA (European Medicines Agency); some approvals as an option only in second- or third-line therapy