Table 3.

Univariate and multivariable analysis of OS in relation to baseline variables in the TOTAL and clean group

Clinical covariates	Total group univariate models HR (95% CI)	p value	Total group multivariable model HR (95% CI)	p value	Clean group univariate models HR (95% CI)	p value	Clean group multivariable models HR (95%)	p value
Age	1.007 (0.992–1.023)	0.371			1.008 (0.990–1.027)	0.369
BMI	0.948 (0.918–0.979)	0.001			0.952 (0.917–0.990)	0.012
Gleason score	0.928 (0.818–1.053)	0.246			0.945 (0.818–1.092)	0.445
ECOG performance status	1.534 (1.325–1.775)	< 0.001	1.486 (1.282–1.723)	< 0.001	1.398 (1.166–1.676)	< 0.001	1.345 (1.121–1.615)	0.001
No. of previous systemic treatments	1.227 (1.098–1.371)	< 0.001			1.212 (1.058–1.389)	0.005
Baseline Hb	0.722 (0.663–0.787)	< 0.001	0.729 (0.669–0.795)	< 0.001	0.709 (0.636–0.787)	< 0.001	0.717 (0.643–0.799)	< 0.001
Baseline PSA	1.001 (1.001–1.001)	< 0.001			1.001 (1.001–1.001)	< 0.001
Baseline tALP	1.001 (1.001–1.002)	< 0.001			1.002 (1.001–1.002)	< 0.001