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. 2020 Aug 11;57(11):4735–4753. doi: 10.1007/s12035-020-02052-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 11 — Effects of the W246G mutant form of ELOVL4 on the photopic ERG a-wave. Homozygous inheritance of the W246G form of ELOVL4 reduces cone-driven ERG a-wave responses. a, b, c Photopic ERG a-wave amplitude for WT, HET, and MUT rats at P90, P120, and 6–7 months of age. d, e, f S-cone-driven ERG a-wave amplitude for WT, HET, and MUT rats at P90, P120, and 6–7 months of age. g, h, i M-cone-driven ERG a-wave amplitude for wild-type, heterozygote, and homozygote SCA34-KI rats at P90, P120, and 6–7 months of age. j, k, l Cone-driven flicker ERG a-wave amplitude for WT, HET, and MUT rats at P90, P120, and 6–7 months of age. (Data shown as mean ± SEM. One-way ANOVA with Tukey’s post hoc test. Asterisks indicate statistical significance at p < 0.05 (*), p < 0.01 (**), and p < 0.001 (***). P90: 14 WT, 14 HET, 17 MUT. P120: 13 WT, 15 HET, 15 MUT. 6–7 Mo: 9 WT, 14 HET, 7 MUT)