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. 2020 Sep 11;11:2176. doi: 10.3389/fimmu.2020.02176

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Copyright © 2020 Lu, Zhou, Gao, Zhou, Li, Zhang, Wang and Gui.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cxcr4/Cxcl12 axis induced IFN activity via MAPK3 and JAK/STAT pathways. (A) CgCxcl12a-A and CgCxcr4b-A combination activated the activity of CaIFN promoter. (B) The activation of CaIFN promoter induced by CgCxcl12a-A and CgCxcr4b-A overexpressing was inhibited by overexpression of dominant negative mutants of MAPK and JAK/STAT signaling molecules. (C) Overexpression of CgCxcl12a-A and CgCxcr4b-A increased the protein expression of p-JAK2, STAT1, p-MAPK3 and MAPK3. (D) The up-regulation protein expression of p-JAK2, STAT1, p-MAPK3, and MAPK3 were suppressed by transfecting dominant negative mutants MAPK3-DN and STAT1a-ΔC+STAT1b-ΔC. Each bar represents mean ± SEM (n = 3). The asterisks indicate the significant differences (**p < 0.01).