Table 2.

Predicted target genes in the top seven enriched gene pathways.

KEGG pathwaya	Genes namesb
sasa04620: Toll-like receptor signaling	CATK; CXL10; IKKA; IRAK1; IRF3; IRF5; IRF7; M3K8; MAPK; MK03; MK13; MP2K2; MP2K4; MYD88; STAT1; TBK1; TL/LRR; TNF-A; TNF-ALPHA-1; TNF-ALPHA-2
sasa04621: NOD-like receptor signaling pathway	BRCC3; CATB; DNM1L; HS90A; HSP90AB1; IKKA; IRF3; IRF7; IRF9; MAPK; MK03; MK13; MYD88; RIPK4; STAT1; STATT2; TBK1; TNF-A; TNF-ALPHA-1; TNF-ALPHA-2; TXNIP
sasa04060: Cytokine-cytokine receptor interaction	CCL19; CCR6; CCR9; CD4; CD40L; CXCR3; CXCR4; CXL10; CXL14; I10R2; I12R2; I13R2; IL-1RL; IL2RB; IL31R; IL4RA; TNF-A; TNF-ALPHA-1; TNF-ALPHA-2; TNF13; TNR14; TNR1A; TNR6; TR11B
sasa04210: Apoptosis	CASP3; CATB; CATF; CATK; CATL1; CATSNE; IKKA; MCL-1; MK03; MP2K2; TNF-A; TNF-ALPHA-1; TNF-ALPHA-2; TNR1A; TNR6
sasa04622: RIG-I-like receptor signaling pathway	CXL10; DHX58; IKKA; IRF3; IRF7; MAPK; MK13; SIKE; TBK1; TNF-A; TNF-ALPHA-1; TNF-ALPHA-2
sasa04625: C-type lectin receptor signaling pathway	L1; C209A; IKKA; IRF9; MAPK; MK03; MK13; NFKB2; STAT1; STAET2; TNF-A; TNF-ALPHA-1; TNF-ALPHA-2
sasa04217: Necroptosis	DNM1L; HS90A; HSP90AB1; IRF9; RIPK4; STAT1; STAET2; STAT4; TNF-A; TNF-ALPHA-1; TNF-ALPHA-2; TNR1A; TNR6

^aThe identification number and the name of the KEGG pathways to which the genes have been mapped (44).

^bTarget genes names are from the Uniprot database (43), all in bold font are targets of HVL-DE miRNAs. The GenBank accession numbers are given in Table S5 along with full gene names.