TABLE 1.
Antibiotics tested and resistance genes identified in the K. pneumoniae isolate
| Drug class | Drug(s) tested | Susceptibility test resulta | Resistance gene(s) |
|---|---|---|---|
| Aminoglycosides | NDb | ND | armA, aac(3)-IV, aac(6')-Ib-cr, aadA1, aadA16, aadA2, aph(3'')-Ib, aph(3')-Ia, aph(4)-Ia, aph(6)-Id |
| Monobactams | Aztreonam | S | None identified |
| Carbapenems | Meropenem | S | None identified |
| β-Lactams (cephalosporins) | Ceftriaxone | S | blaDHA-1, blaSHV-28 |
| Cefepime | S | ||
| Cefuroxime | R | ||
| Cefixime | R | ||
| Penicillins | Piperacillin | R | |
| Ampicillin-sulbactam | R | ||
| Fluoroquinolones | Levofloxacin | R | oqxA, oqxB, qnrB2, qnrB4 |
| Moxifloxacin | R | ||
| Tetracyclines | Tetracycline | I | None identified |
| Tigecycline | I | ||
| Minocycline | S | ||
| Phenicols | Chloramphenicol | R | cmlA1, floR |
| Rifampin | ND | ND | ARR-3 |
| Trimethoprim | Trimethoprim | R | dfrA27 |
| Fosfomycin | ND | ND | fosA, mdf(A) |
| Macrolides | ND | ND | mph(E), msrE |
| Sulfonamides | ND | ND | sul1, sul3 |
| Polymyxins | Colistin | S (I/R)c | mcr-8 |
a
Resistance classifications are based on CLSI guidelines (16) and the Vitek 2 Advanced Expert System. S, susceptible; R, resistant; I, intermediate.
b
ND, not done.
c
The isolate tested intermediate on the Vitek 2 system and the Etest and resistant on the MicroScan system using the 2020 CLSI breakpoints (17).