Figure 1.

Purine degradation pathway induced by fructose. Fructose can come from the diet or be endogenously produced by the polyol pathway. In turn, the metabolism of fructose by fructokinase C (KHK-C) can lead to ATP consumption, with intracellular phosphate depletion, resulting in activation of AMP deaminase (AMPD) that eventually leads to the production of uric acid. Key: green color shows the sources of fructose, the blue color the caloric pathway of fructose metabolism, and the red color the pathway involving nucleotide degradation that activates the survival pathway.