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. 2020 Jul 25;22:273–284. doi: 10.1016/j.omtn.2020.07.031

Figure 2.

Figure 2

Knockdown of TLR2 Improves Myocardial Mitochondrial Dysfunction in LPS-Induced Septic Mice

(A) Observation of myocardial mitochondrial structure under a transmission electron microscope in mice treated with LPS or in combination with sh-TLR2 (20,000×). (B) Measurement of the swelling degree of myocardial mitochondria in mice treated with LPS or in combination with sh-TLR2. (C) Measurement of mitochondrial ATP level in the supernatant upon treatment with LPS or in combination with sh-TLR2. (D) Detection of MMP by JC-1 assay in mice treated with LPS or in combination with sh-TLR2. (E and F) Correlation analysis of TLR2 expression with the myocardial mitochondrial swelling degree (E) and mitochondrial ATP level (F) in myocardial tissues of mice treated with LPS or in combination with sh-TLR2. ∗p < 0.05 versus the LPS + sh-NC group (LPS-induced mice treated with lentivirus carrying sh-NC). Measurement data were expressed as mean ± standard deviation. Comparison between two groups was conducted by unpaired t test. n = 12 for mice upon each treatment.