Figure 3.

Knockdown of TLR2 Decreases Chemokine Production in LPS-Induced Septic Mice

(A) PPI network of differentially expressed genes in the GSE53007 microarray dataset. Red indicates the core gene. (B) Determination of serum CXCL1 levels by ELISA in mice treated with LPS or in combination with sh-TLR2. (C) Determination of serum CXCL9 levels by ELISA in mice treated with LPS or in combination with sh-TLR2. (D) Determination of serum CCL5 levels by ELISA in mice treated with LPS or in combination with sh-TLR2. (E) Determination of serum CCL7 levels by ELISA in mice treated with LPS or in combination with sh-TLR2. ∗p < 0.05 versus the LPS + sh-NC group (LPS-induced mice treated with lentivirus carrying sh-NC). Measurement data were expressed as mean ± standard deviation. Comparison between two groups was performed using unpaired t test. n = 12 for mice upon each treatment.