TABLE 1.

HDACs family members.

Class	Homology to yeast	Human HDACs	Deacetylase activity cofactors	Cellular localization
I	Rpd3	HDAC 1, HDAC 2, HDAC 3, and HDAC 8	Zinc dependent	Nucleus
II	Hda1	Class IIA: HDAC 4, HDAC 5, HDAC 7, and HDAC 9	Zinc dependent	Nucleus and cytoplasm
		Class IIB: HDAC 6 and HDAC 10
III	Sir2	SIRT 1, SIRT 2, SIRT 3, SIRT 4, SIRT 5, SIRT 6, SIRT 7	NAD+ dependent	Nucleus, cytoplasm, and mitochondria
IV	HOS3	HDAC 11	Zinc dependent	Nucleus and cytoplasm