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. 2020 Sep 11;8:1009. doi: 10.3389/fbioe.2020.01009

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Copyright © 2020 McLaughlin, Beal, Mısırlı, Grünberg, Bartley, Scott-Brown, Vaidyanathan, Fontanarrosa, Oberortner, Wipat, Gorochowski and Myers.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A multicellular communication system represented using SBOL3. Two different organisms implement a sender and receiver system, which uses a small molecule (AHL) as a signal. The sender and receiver systems are represented by Components and use constraints to show that each of these cell types contains AHL (not shown are details of the genetic system and its interactions with the molecule). These sender and receiver systems are SubComponents of the overall multicellular system, which is also represented by a Component. The fact that AHL is shared between the two systems is captured using an identity constraint. A serialized SBOL3 representation of this construct is available on GitHub at https://github.com/SynBioDex/SBOLTestSuite/tree/master/SBOL3/multicellular.