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. 2020 Sep 10;11:1820. doi: 10.3389/fimmu.2020.01820

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Copyright © 2020 Caputo, Grioni, Brambillasca, Monno, Brevi, Freschi, Piras, Elia, Pieri, Baccega, Lombardo, Galli, Briganti, Doglioni, Jachetti and Bellone.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gal-3 balances cancer malignancy in the early phases of prostate cancer development. In the early phases of disease development and metastasis CSCs, through Gal-3, drive prostate cancer malignancy, and immunosuppression.