FIGURE 1.
Cellular and MCMV markers used in this study. (A) Subcellular distribution of host-cell markers in membranous organelles indicates major sites of their retention or activation/recruitment to membranes (For references see Supplementary Table S2). Markers that circulate within the membranous system are labeled in red. EE, early endosome; ER, endoplasmic reticulum; ERC, endosomal recycling compartment; ERGIC, endoplasmic reticulum-Golgi intermediate compartment; LE, late endosome; LRO, lysosome-related organelles; LY, lysosome; MVB, multivesicular body; SE, sorting endosome; TGN, trans-Golgi network. C1-C7, cisternae of the Golgi stack. (B) Organization of the MCMV life cycle and expression kinetics of MCMV genes that encode proteins of interest for this study. The schematic presentation is based on the published data (Scrivano et al., 2010; Marcinowski et al., 2012; Kutle et al., 2017). IE, immediate early phase; E, early phase; L, late phase; 11/2-column fitting image.