Supplementary Figure 7.

ACE2-associated subnetworks reveal gut epithelial cell type enrichment. Each ACE2-associated subnetwork was interrogated for enrichment with: (A) Genes co-correlated with ACE2 in colonocytes was curated from Wang et al²⁸; (B) gut cell type associated signatures from (Huang et al, 2019²⁶) and (C) (Smillie et al, 2019²⁵). (D) Gene sets associated with various perturbations in macrophages.²⁷ The number of genes within each ACE2-associated subnetwork are: control ileum = 221; CD ileum = 235; control colon = 229; CD colon = 235; and UC colon = 346. The heatmap coloring depicts the fold enrichment and the level of significance based on BH adj P value of ∗P < .1) ∗∗P < . 05, or ∗∗∗P < . 01. The full enrichment results are available in Supplementary Tables 9 to 12.