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. 2020 Sep 25;160(1):287–301.e20. doi: 10.1053/j.gastro.2020.09.029

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© 2021 by the AGA Institute.

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Supplementary Figure 9 — TMPRSS2-associated subnetworks reveal gut cell type enrichment. Each of the 4 TMPRSS2-associated subnetworks were examined for enrichment with various gut cell type related signatures (Smillie et al, 2019²⁵) (A) (Huang et al, 2019²⁶). (B) The number of genes within each TMPRSS2-associated subnetworks are as follows: CD ileum = 397; control colon = 268; CD colon = 366; and UC colon = 490. The heatmap coloring depicts the fold enrichment and the level of significance based on BH adj P value of ∗P < .1, ∗∗P < . 05, or ∗∗∗P < . 01). The full enrichment results are available in Supplementary Tables 15 and 16.