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(A) Time-kill kinetic curves of S2 at 0.125 MIC, 0.25 MIC, 0.5 MIC, MIC, and 2 MIC against S. aureus 29213. (B) Emergence of bacterial resistance after treatment of S. aureus 29213 with antimicrobials for 15 days at sub-MIC concentration determined by sequential passaging method. The fold change in MIC of the antimicrobials was plotted against the number of days.
