Table 1. Genome-Wide Significant Loci Associated With Tinnitus in the UKB Cohort and Replication in the MVP Cohort.

Marker	Chromosome No.	Positiona	Allele 1	Allele 2	Allele 1 frequency	UKB discovery cohort (n = 172 995)			MVP replication cohort (n = 260 832)			Direction of effectc	Predicted genes in risk locus
						INFO score	β coefficient (SE)	P value	Allele 1 frequency	OR (SE)	P valueb
rs143424888	1	103456996	C	Insd	0.510	0.973	0.023 (0.004)	8.5 × 10−9	0.505	1.040 (0.006)	1.4 × 10−10	Same	COL11A1, RNPC3
rs17249745	4	102547366	A	G	0.967	0.897	–0.072 (0.012)	1.3 × 10−9	0.964	1.014 (0.016)	.38	Opposite	BANK1
rs553448379	6	43288656	T	TA	0.386	0.989	–0.023 (0.004)	2.1 × 10−8	0.403	0.979 (0.006)	2.28 × 10−4	Same	CCND3, TAF8, GLTSCR1L, C6orf226, CNPY3, GNMT, PEX6, MEA1, KLHDC3, RRP36, CUL9, DNPH1, TTBK1, SLC22A7, CRIP3, ZNF318, ABCC10, DLK2, LRRC73, POLR1C, YIPF3, POLH, MRPS18A, SLC29A1
rs11249981	8	10147398	C	T	0.447	0.990	–0.022 (0.004)	4.6 × 10−8	0.465	0.978 (0.006)	1.14 × 10−4	Same	ERI1, TNKS, MSRA
rs72815660	10	106614698	A	G	0.960	0.986	–0.060 (0.010)	9.7 × 10−9	0.958	1.001 (0.015)	.97	Opposite	SORCS3
rs11174489	12	62852271	G	A	0.625	0.995	–0.024 (0.004)	3.8 × 10−9	0.646	1.001 (0.006)	.85	Opposite	MON2, C12orf61, PPM1H, TMEM5

Abbreviations: A, adenosine; C, cytosine; G, guanidine; INFO, imputation information score; Ins, insertion variant; MVP, Million Veteran Program; OR, odds ratio; SE, standard error; T, thymidine; UKB, UK Biobank.

^aIndicates base pair position on chromosome (GR37 Human Genome Build hg19).

^bSignificance in MVP at P < .00833 (Bonferroni-correction for the 6 loci tested for replication).

^cIndicates comparison of single-nucleotide variation effect between UKB and MVP.

^dInsertion of CACGTGATCT.