Figure 3. Quality of Life, Bone Pain, and Thrombopenia.

A, Patients’ measured global health status per treatment cycle. Higher score is better. B, Patient response to the measure of bone pain at its worst in the past 24 hours each day during cycle 1 expressed as a percentage change from baseline pain using the Brief Pain Inventory Short Form. Error bars indicate 95% CIs; a negative score indicates less pain. C, Patient response to the measure of bone pain on average in the past 24 hours each day during cycle 1 expressed as a percentage change from baseline pain using the Brief Pain Inventory Short Form. Error bars indicate 95% CIs; a negative score indicates less pain. D, Platelet counts by day during treatment cycle 1 expressed as percentage change from baseline. P values were based on the mixed-model repeated measures method with the terms of treatment, baseline value, postbaseline visit, and treatment by postbaseline visit interactions. The covariance is assumed to be compound symmetry