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. 2020 Sep 11;11:567274. doi: 10.3389/fimmu.2020.567274

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Copyright © 2020 Boneva, Wolf, Rosmus, Schlecht, Prinz, Laich, Boeck, Zhang, Hilgendorf, Stahl, Reinhard, Bainbridge, Schlunck, Agostini, Wieghofer and Lange.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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High throughput sequencing characterization of human hyalocytes. (A) Heatmap of the most prominent transcripts in human hyalocytes sorted by transcripts per million (TPM). The color bars on the top of the heatmap reveal diagnosis of study subjects (pink for macular pucker, lilac for macular hole), sex (grass-green for male, orange for female), and age (age scale bar legend to the right). (B) Most significant Gene ontology biological process (BP) clusters of the 100 most highly expressed mRNA transcripts in hyalocytes. Color coding of the dots according to the p-adjusted value, size of the dots according to the count of transcripts associated with the respective GO term. (C) Top five most highly expressed transcripts in the five enriched GO terms in B. (D) Immunohistochemical staining for FTL. Higher magnification of a vitreal cell is presented in the upper right corner. Nuclei are counterstained with DAPI (4’,6-Diamidin-2-phenylindol). DIC, differential interference contrast; GCL, ganglion cell layer; INL, inner nuclear layer; ONL, outer nuclear layer; and RPE, retinal pigment epithelium. (E) Immunohistochemical staining for CD74. Higher magnification of a vitreal cell is presented in the upper right corner. Nuclei are counterstained with DAPI (4’,6-Diamidin-2-phenylindol). DIC, differential interference contrast; GCL, ganglion cell layer; INL, inner nuclear layer; and ONL, outer nuclear layer.