Table 2. In vitro antileishmanial activity of 3-nitro-isoxazole-4-carboxamides (3) against L. donovani.

Compd. no	IC50 (μM)		CC50 (μM)	SI index
	Promastigote	Amastigote
3ba	NI	NI	ND	ND
3bb	NI	NI	ND	ND
3bc	NI	NI	ND	ND
3be	3.52 ± 0.04	2.06 ± 0.01	69.6 ± 1.55	33.78
3bg	NI	NI	ND	ND
3bh	NI	NI	ND	ND
3bi	NI	NI	ND	ND
3bj	1.3 ± 0.04	Toxic	ND	ND
3bl	3.07 ± 0.08	21.3 ± 0.28	76.2 ± 0.14	3.57
3bm	3.01 ± 0.06	17.35 ± 0.07	66.95 ± 0.49	3.85
3bn	2.83 ± 0.03	21.9 ± 0.28	76.45 ± 0.21	3.49
3bo	ND	ND	ND	ND
3bp	2.71 ± 0.26	15.6 ± 0.14	65.95 ± 0.63	4.22
3ea	2.81 ± 0.19	3.56 ± 0.02	89.3 ± 0.14	25.08
3eb	NI	NI	ND	ND
3ec	1.16 ± 0.49	19.45 ± 0.35	91.9 ± 0.98	4.72
3ee	2.67 ± 0.05	9.41 ± 0.07	89.49 ± 0.07	9.50
3eg	NI	NI	ND	ND
3eh	2.79 ± 0.08	3.43 ± 0.02	68.55 ± 0.49	19.98
3ei	2.90 ± 0.03	19.6 ± 0.42	73.7 ± 0.70	3.76
3ej	3.05 ± 0.06	3.22 ± 0.21	106.35 ± 0.49	33.02
3el	NI	NI	ND	ND
3em	NI	NI	ND	ND
3en	NI	NI	ND	ND
3eo	ND	ND	ND	ND
3ep	NI	NI	ND	ND
3ka	2.68 ± 0.05	5.97 ± 0.23	67.3 ± 0.84	11.27
3kb	1.32 ± 0.03	Toxic	ND	ND
3kc	2.46 ± 0.02	50.6 ± 0.98	86.35 ± 0.91	1.70
3ke	3.42 ± 0.04	2.03 ± 0.02	80.5 ± 1.27	39.65
3kg	3.05 ± 0.03	7.74 ± 0.04	71.2 ± 0.28	9.19
3kh	3.02 ± 0.02	11.3 ± 0.28	61.15 ± 0.77	5.41
3ki	3.49 ± 0.05	1.41 ± 0.01	81.8 ± 1.37	58.01
3kj	5.24 ± 0.10	1.95 ± 0.02	81.75 ± 0.35	41.92