Skip to main content
. 2020 Jul 20;11(9):1053–1062. doi: 10.1039/d0md00083c

Table 5. In vivo antileishmanial activity against L. donovani in a golden hamster model.

Compd. no Percentage inhibition
Route of administration Dose mg kg–1
7th day 28th day
1h 36.0 ± 8.48 NI IP 50
1k 39.5 ± 0.70 29.0 ± 0.0 IP 50
1m 36.0 ± 20.20 71.25 ± 10.56 IP 50
1m 48.41 ± 11.44 66.03 ± 8.74 Oral 100
4bb 44.02 ± 12.63 75.20 ± 6.64 IP 50
4kd 29.22 ± 41.32 NI IP 50
4kk 50.92 ± 8.48 38.04 ± 2.6 IP 50
4md 13.51 ± 0.6 2.08 ± 3.6 IP 50
4mf 71.08 ± 11.11 28.63 ± 11.04 IP 50
4mf 69.47 ± 8.34 12.70 ± 8.91 Oral 100
6ba NI NI IP 50
6gc NI NI IP 50
6ka 19.32 ± 3.06 NI IP 50
6kb 61.99 ± 2.46 9.23 ± 6.12 IP 50
6mc 20.01 ± 8.22 4.38 ± 5.28 IP 50
Miltefosine 97.32 ± 0.55 98.41 ± 1.41 Oral 30