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Increased capacity of IL-2 production by J.CaM2 cells expressing the LATG131D mutant. J.CaM2 cells expressing human WT-LAT or the LATG131D mutant were stimulated with anti-CD3/CD28 microbeads for the indicated time in hours, and the amount of IL-2 in supernatants was measured by ELISA. The values presented are mean values of four (for 24 h incubation) or eleven (for 48 h) separate experiments. Bars represent the standard error. The asterisk represents statistical significance.
