TABLE 1.
Demographic and clinicopathological variables in cases (dogs that experienced adverse events) and controls (dogs that did not experience adverse events) with primary brain tumors subjected to stereotactic brain biopsy
| Cases (n = 8) | Controls (n = 21) | P value | |
|---|---|---|---|
| Subject variables a | |||
| Age (years) | 8.5 (1.5) | 8.0 (1.8) | .45 |
| Weight (kg) | 21.8 (12.8) | 24.8 (10.6) | .51 |
| Baseline Karnofsky Performance Score | 77 (10.4) | 81.7 (9.1) | .34 |
| Tumor type and grade (%; proportion) | |||
| Low‐grade astrocytoma | 12 (1/8) | 10 (2/21) | .82 |
| High‐grade astrocytoma | 25 (2/8) | 29 (6/21) | .74 |
| Low‐grade oligodendroglioma | 0 | 19 (4/21) | .25 |
| High‐grade oligodendroglioma | 63 (5/8) | 33 (7/21) | .16 |
| Low‐grade unclassified glioma | 0 | 5 (1/21) | .72 |
| Meningioma | 0 | 5 (1/21) | .72 |
| Tumor volumes a | |||
| Tumor volume (cm3) | 4.39 (1.47) | 3.94 (3.30) | .28 |
| Tumor:brain volume ratio | .059 (.014) | .044 (.032) | .09 |
| Biopsy technical variables | |||
| Biopsy needle path length (mm) a | 36 (15.7) | 29.9 (13.3) | .30 |
| Number of biopsies (median, range) b | 2 (1–3) | 2 (1‐5) | .19 |
| Laboratory variables a | |||
| Albumin (g/dL) | 3.49 (.29) | 3.21 (.36) | .09 |
| Globulin (g/dL) | 3.33 (.36) | 3.15 (.43) | .44 |
| ALT (U/L) | 21 (77) | 214 (337) | .92 |
| ALP (U/L) | 1052 (1400) | 912 (1731) | .55 |
| Creatine kinase (U/L) | 122.3 (29.7) | 140.4 (47.4) | .62 |
| RBC (×106 cells/mm3) | 6.726 (.99) | 6.554 (.71) | .77 |
| WBC (×103 cells/mm3) | 12.88 (3.64) | 10.82 (3.77) | .16 |
| Platelets (×103 cells/mm3) | 194.75(108.32) | 284.29(68.54) | .006* |
a
Data presented as mean (SD).
b
Data presented as median (range).
*
Statistically significant, P < .05.