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. 2020 Sep 11;11:576651. doi: 10.3389/fimmu.2020.576651

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Copyright © 2020 Govender, Mikulic, Wyss, Gaide, Thome and Golshayan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Malt1-deficiency prolongs MHC-mismatched skin graft survival. (A) To evaluate the role of TCR signaling mediated via Malt1 in alloresponses, recipient Malt1-ko and wild-type (Wt) B6 mice received a MHC-mismatched B6D2 skin allograft. As a comparison group, Wt mice were treated with cyclosporine A (CsA) i.p. daily after transplantation. (B) Graft survival. Graft draining lymph nodes (dLN) were harvested at rejection and analyzed by flow cytometry. (C,D) Frequency of CD4⁺ and CD8⁺ T cells, respectively. (E,F) Mean fluorescence intensity (MFI) of CD44 on the surface of CD4⁺ and CD8⁺ T cells, respectively. (G–L) Detection of intracellular cytokines after brief in vitro restimulation. (G,J) IFN-γ, (H,K) IL-2, (I,L) IL-17; in CD4⁺ and CD8⁺ T cells, respectively. n = 5 mice/group. MST, median survival time.