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. 2020 Sep 11;11:576651. doi: 10.3389/fimmu.2020.576651

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Copyright © 2020 Govender, Mikulic, Wyss, Gaide, Thome and Golshayan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Allograft rejection in Malt1-ko mice correlates with a lack of peripheral Treg and elevated IL-17-producing T cells early after transplantation. Graft draining lymph nodes (dLN) of wild-type (Wt) B6 and Malt1-ko recipients were analyzed by flow cytometry at days 7 and 10 post transplantation of B6D2 skins. Frequency of (A) CD4⁺Foxp3⁺ T cells. (B,C) Mean fluorescence intensity (MFI) of CD44 and CD62L expression on the surface of CD4⁺ and CD8⁺ T cells, respectively. (D–G) Detection of intracellular cytokines after brief in vitro restimulation. (D,E) IFN-γ, (F,G) IL-17; in CD4⁺ and CD8⁺ T cells, respectively. n = 5 mice/group.