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. 2020 Sep 11;11:576651. doi: 10.3389/fimmu.2020.576651

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Copyright © 2020 Govender, Mikulic, Wyss, Gaide, Thome and Golshayan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Malt1-deficiency promotes tolerance to minor histocompatibility antigens-mismatched skin grafts. (A) Male B6 skins were transplanted to wild-type (Wt) and Malt1-ko female B6 mice that were left untreated or received cyclosporine A (CsA) i.p. daily after transplantation. (B) Graft survival. (C,D) Frequency of CD4⁺CD25⁺ and CD4⁺Foxp3⁺ T cells, respectively. (E,I) Mean fluorescence intensity (MFI) of CD44 on the surface of CD4⁺ and CD8⁺ T cells, respectively. (F–L) Detection of intracellular cytokines after brief in vitro restimulation. (F,J) IFN-γ, (G,K) IL-2, (H,L) IL-17; in CD4⁺ and CD8⁺ T cells, respectively. n = 5 mice/group. MST, median survival time.