FIGURE 4.

Cyclosporine A treatment gradually decreases peripheral Treg whilst increasing activated effector T cells in Wt and Malt1-ko mice. Male B6 skins were transplanted to wild-type (Wt) and Malt1-ko female B6 mice that were left untreated or received cyclosporine A (CsA) i.p. daily after transplantation. The recipient mice were tail-bled the day before transplantation (d-1), then at day 6 and 15 post transplantation. (A,B) Mean fluorescence intensity (MFI) of CD44 expression on the surface of CD4⁺ and CD8⁺ T cells, respectively. (C,D) Frequency of CD4⁺CD25⁺ and CD4⁺Foxp3⁺ T cells. n = 5 mice/group.