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. 2020 Sep 11;11:576651. doi: 10.3389/fimmu.2020.576651

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Copyright © 2020 Govender, Mikulic, Wyss, Gaide, Thome and Golshayan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Constitutive inhibition of Malt1 protease activity in Malt1-ki mice only slightly delays graft rejection. (A) Recipient Malt1-ki, Malt1-ko and Wt B6 mice received a MHC-mismatched B6D2 skin graft. (B) Graft survival. CD4⁺ and CD8⁺ T-cell responses in the graft draining LN (dLN) were analyzed by flow cytometry. (C) Mean fluorescence intensity (MFI) of CD44 expression on the surface of CD4⁺ and CD8⁺ T cells. Frequency of (D) CD4⁺CD25⁺Foxp3⁺ T cells, (E) IFN-γ⁺ CD4⁺ and CD8⁺ T cells, (F) IL-17⁺ CD4⁺ T cells. n = 4–6 mice/group. MST, median survival time.