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. 2020 Sep 21;20(5):262. doi: 10.3892/ol.2020.12125

Figure 1.

Figure 1.

GRP78 regulates LINC00294 expression. (A) The top 200 lncRNAs that were positively correlated with GRP78 in the GSE26511, GSE5787 and TCGA datasets. (B) The top 200 lncRNAs that were negatively correlated with GRP78 in the GSE26511, GSE5787 and TCGA datasets. (C) The GRP78 protein expression level was decreased by transfection with si-GRP78. (D) LINC00294 expression was decreased following GRP78-knockdown. (E) LINC00294 is associated with the cell cycle according to GSEA. (F) GSEA demonstrated that LINC00294 is enriched in the Hedgehog pathway. ***P<0.001. GRP78, glucose-regulated protein 78; lncRNA, long non-coding RNA; TCGA, The Cancer Genome Atlas; si, small interfering RNA; NC, negative control; HCP5, HLA complex 5; HOTAIRM1, HOXA transcript antisense RNA, myeloid specific 1; HOXA11-AS, HOXA11 antisense; ST3GAL4-AS1, ST3GAL4 antisense RNA 1; TOPORs-AS1, TOPORS antisense RNA 1; ES, enrichment score; KEGG, Kyoto Encyclopedia of Genes and Genomes; GSEA, Gene Set Enrichment Analysis.