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. 2020 Sep 25;15:223. doi: 10.1186/s13014-020-01662-9

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — One-way analysis of variance for hearing threshold and relative balance ability showed the changes among the different groups after irradiation and resolvin E1-pretreatment. ^*, P ≤ 0.05; ^**, P ≤ 0.01; a. Hearing changes after irradiation and resolvin E1-pretreatment. Irradiation-induced hearing loss, which was obvious on days 7 and 14 after irradiation; resolvin E1 (RvE1) mitigated the irradiation-induced hearing loss. The red asterisk indicates a comparison between the Sham/WT and Rad groups. The black asterisk indicates a comparison between the Rad and Rad+RvE1 groups. b. Relative balance ability changes after irradiation and resolvin E1-pretreatment. The relative balance ability in Sham/WT, RvE1, Rad and Rad+RvE1 groups were respectively 1.154 ± 0.171, 1.149 ± 0.133, 0.869 ± 0.085, and 1.039 ± 0.115 on day 7 and 1.137 ± 0.151, 1.134 ± 0.161, 0.927 ± 0.066, and 1.048 ± 0.094 on day 14. Irradiation induced damage in relative balance ability (compared between the Sham/WT and Rad groups) on days 7 and 14 after irradiation (P = 0.0045 and P = 0.0107), and RvE1 mitigated this damage (comparison between the Rad and Rad+RvE1 groups, P = 0.0155 on day 7 and P = 0,0270 on day 14)